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Description for Protein IKBKB

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
59 total interacting proteins; 28 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.10
    KEGG - Orthology:
    K07209
    KEGG - Pathway(s):
    hsa04010; hsa04062; hsa04210; hsa04620; hsa04621; hsa04622; hsa04623; hsa04660; hsa04662; hsa04722; hsa04910; hsa04920; hsa04930; hsa05120; hsa05131; hsa05142; hsa05200; hsa05212; hsa05215; hsa05220; hsa05221; hsa05222
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Inhibitor of kappa light chain gene enhancer in B cells, kinase of, beta; Nuclear factor of kappa light chain gene enhancer in B cells inhibitor, kinase of, beta; NFKBIKB; I-kappa-B kinase beta; IKKB; I-kappa-B kinase 2; IKK2; Inhibitor of nuclear factor kappa B kinase beta subunit; IKK-B; Nuclear factor NF-kappa-B inhibitor kinase beta
    Approved Symbol:
    IKBKB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 21
    Human (de-) phosphorylation sites: 21; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 16
    Human phosphorylation targets: 16; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Arsenic trioxide(db);
  • Auranofin(db);
  • Mesalazine(db);
  • Sulfasalazine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04462 Entrez Gene ID: 3551 OMIM ID: 603258 Swissprot Accession: O14920;