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Description for Protein FAS

Fas (TNF receptor superfamily, member 6)
50 total interacting proteins; 27 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TNFR: Tumor necrosis factor receptor / nerve growth factor receptor repeats.
  • TM: Transmembrane domain
  • DEATH: DEATH domain, found in proteins involved in cell death (apoptosis).
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04390
    KEGG - Pathway(s):
    hsa04010; hsa04060; hsa04115; hsa04210; hsa04650; hsa04940; hsa05010; hsa05142; hsa05200; hsa05320; hsa05330; hsa05332
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Tumor necrosis factor receptor superfamily, member 6 isoform 4; Tumor necrosis factor receptor superfamily, member 6 isoform 6; Tumor necrosis factor receptor superfamily member 6 isoform 2; Tumor necrosis factor receptor superfamily member 6 isoform 3; Tumor necrosis factor receptor superfamily member 6 isoform 4; Tumor necrosis factor receptor superfamily member 6 isoform 5; Tumor necrosis factor receptor superfamily member 6 isoform 7; Apo-1 Fas; OTTHUMP00000059646; Tumor necrosis factor receptor superfamily member 6 isoform 1; TNFRSF6; Tumor necrosis factor receptor superfamily member 6; APT1; FAS antigen; Surface antigen apo1; APO1; CD95; Apoptosis antigen 1; Apoptosis mediating surface antigen FAS; FAS1; ALPS1A; FASTM; APO-1 cell surface antigen; CD95 antigen
    Approved Symbol:
    FAS
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 13
    Human (de-) phosphorylation sites: 13; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Autoimmune lymphoproliferative syndrome, type Ia(Pd);
  • Autoimmune lymphoproliferative syndrome, type Ia, autosomal recessive(Pd);
  • Lung cancer, susceptibility to(Pd);
  • Squamous cell carcinoma, burn scar-related, somatic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 8 : 0
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00609 Entrez Gene ID: 355 OMIM ID: 134637 Swissprot Accession: Q5T9P3; P25445;