Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein IGLL1

immunoglobulin lambda-like polypeptide 1
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • IGC: Immunoglobulin C-Type
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06554
    KEGG - Pathway(s):
    hsa05340
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    14.1; IGVPB; VPREB2; IGLJ14.1; CD179b antigen; Pre-B lymphocyte-specific protein-2; Immunoglobulin lambda-like polypeptide 1 isoform a precursor; Immunoglobulin lambda-like polypeptide 1 isoform b precursor; Lambda5; IGLL; Immunoglobulin omega polypeptide; Immunoglobulin lambda like polypeptide 1; IGO; IGL5; IGL1; Immunoglobulin related 14.1 protein
    Approved Symbol:
    IGLL1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Agammaglobulinemia, autosomal recessive(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00905 Entrez Gene ID: 3543 OMIM ID: 146770 Swissprot Accession: P15814; Q0P681;