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Description for Protein KLK3

kallikrein-related peptidase 3
19 total interacting proteins; 12 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TRYPSIN: Trypsin-like serine protease
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.21.77
    KEGG - Orthology:
    K01351
    KEGG - Pathway(s):
    hsa05200; hsa05215
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Prostate specific antigen isoform 3 preproprotein; Prostate specific antigen isoform 1 preproprotein; Prostate specific antigen isoform 4 preproprotein; Prostate specific antigen isoform 5 preproprotein; Prostate specific antigen isoform 6 preproprotein; Prostate specific antigen; PSA; Gamma seminoprotein; Semenogelase; Seminin; P-30 antigen; APS; KLK2A1; HK3; EC 3.4.21.77
    Approved Symbol:
    KLK3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 6 : 1
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01461 Entrez Gene ID: 354 OMIM ID: 176820 Swissprot Accession: Q15096; P07288; C9JXH3;