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Description for Protein APP

amyloid beta (A4) precursor protein
93 total interacting proteins; 51 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 5/3)
(alpha granules: 1; membrane: 1; platelet: 2; secretome: 3; undefined: 2)
Summary:
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • CC: Coiled Coil
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04520
    KEGG - Pathway(s):
    hsa05010
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CVAP; PN2; ABPP; Cerebral vascular amyloid peptide; Protease nexin II; PN II; APPI; PreA4; AAA; ABETA; AD1; CTFgamma; A4 amyloid protein; Amyloid-beta protein; APP751; Amyloid beta A4 protein isoform b; Amyloid beta A4 protein isoform c; Amyloid beta A4 protein isoform a
    Approved Symbol:
    APP
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 43
    Human (de-) phosphorylation sites: 43; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Methionine Sulfoxide(db)

    Associated Genetic Diseases:

  • Alzheimer disease, early-onset, with cerebral amyloid angiopathy(Pd);
  • Alzheimer disease, familial, 1(Pd);
  • Amyloidosis, cerebroarterial, hereditary, Iowa type(Pd);
  • Amyloidosis, cerebroarterial, hereditary, Italian type(Pd);
  • Amyloidosis, with cerebral hemorrhage, hereditary, Dutch type(Pd);
  • APP polymorphism(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 5 : 1
  • Isoform 4 : 1
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00100 Entrez Gene ID: 351 OMIM ID: 104760 Swissprot Accession: B4DGD0; P05067;