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Description for Protein NMNAT3

nicotinamide nucleotide adenylyltransferase 3
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 4)
Summary:
The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca(2+) signaling pathways. NMNAT (EC 2.7.7.1) is a central enzyme in NAD biosynthesis, catalyzing the condensation of nicotinamide mononucleotide (NMN) or nicotinic acid mononucleotide (NaMN) with the AMP moiety of ATP to form NAD or NaAD (Zhang et al., 2003 [PubMed 12574164]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.7.7.1; 2.7.7.18
KEGG - Orthology:
K06210
KEGG - Pathway(s):
hsa00760; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
PNAT3; Pyridine nucleotide adenylyltransferase 3; EC 2.7.7.1; NMN adenylyltransferase 3; FKSG76 protein; Nicotinamide nucleotide adenylyltransferase 3
Approved Symbol:
NMNAT3
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alpha,Beta-Methyleneadenosine-5'-Triphosphate(db);
  • Deamido-Nad+(db);
  • Nicotinamide Mononucleotide(db);
  • Nicotinamide-Adenine-Dinucleotide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 16370 Entrez Gene ID: 349565 OMIM ID: 608702 Swissprot Accession: Q96T66;