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Description for Protein IGF1R

insulin-like growth factor 1 receptor
58 total interacting proteins; 39 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(membrane: 1)
Summary:
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • FU: Furin-like repeats
  • REC: cheY-homologous receiver domain
  • FN3: Fibronectin type 3 domain
  • TM: Transmembrane domain
  • Tyr_Kinase: tyrosine kinase domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.1
    KEGG - Orthology:
    K05087
    KEGG - Pathway(s):
    hsa04114; hsa04144; hsa04510; hsa04520; hsa04730; hsa04914; hsa05200; hsa05214; hsa05215; hsa05218
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    IGF1 receptor; CD221 antigen; Insulin like growth factor I receptor
    Approved Symbol:
    IGF1R
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 30
    Human (de-) phosphorylation sites: 30; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 18
    Human phosphorylation targets: 4; Predicted platelet targets: 14
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione(db);
  • 3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE(db);
  • Alpha-D-Mannose(db);
  • Fucose(db);
  • Insulin Glargine(db);
  • Insulin Lispro(db);
  • Insulin recombinant(db);
  • Insulin, porcine(db);
  • Mecasermin(db);
  • Phosphoaminophosphonic Acid-Adenylate Ester(db)

    Associated Genetic Diseases:

  • Insulin-like growth factor I, resistance to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00932 Entrez Gene ID: 3480 OMIM ID: 147370 Swissprot Accession: P08069;