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Description for Protein IGF1

insulin-like growth factor 1 (somatomedin C)
15 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05459
    KEGG - Pathway(s):
    hsa04114; hsa04115; hsa04150; hsa04510; hsa04730; hsa04914; hsa04960; hsa05200; hsa05214; hsa05215; hsa05218; hsa05410; hsa05414
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    IGFI; Somatomedin C; Insulin like growth factor IB prepropeptide
    Approved Symbol:
    IGF1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Deoxy-Bigchap(db);
  • N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate(db)

    Associated Genetic Diseases:

  • Insulin-like growth factor I deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00936 Entrez Gene ID: 3479 OMIM ID: 147440 Swissprot Accession: Q5U743; Q59GC5; P05019;