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Description for Protein IFNGR2

interferon gamma receptor 2 (interferon gamma transducer 1)
6 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • FN3: Fibronectin type 3 domain
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05133
    KEGG - Pathway(s):
    hsa04060; hsa04630; hsa04650; hsa05140; hsa05142
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Interferon gamma receptor beta chain; IFGR2; Interferon gamma transducer 1; IFNGT1; Interferon gamma receptor accessory factor 1; AF-1
    Approved Symbol:
    IFNGR2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Interferon gamma-1b(db)

    Associated Genetic Diseases:

  • Atypical mycobacterial infection, familial disseminated(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 00956 Entrez Gene ID: 3460 OMIM ID: 147569 Swissprot Accession: P38484; A8K881;