Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein IFNGR1

interferon gamma receptor 1
11 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05132
    KEGG - Pathway(s):
    hsa04060; hsa04630; hsa04650; hsa05140; hsa05142
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    AVP type II; Immune interferon receptor 1; IFNG receptor; CD119 antigen; CD119
    Approved Symbol:
    IFNGR1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Interferon gamma-1b(db)

    Associated Genetic Diseases:

  • Atypical mycobacterial infection, autosomal dominant(Pd);
  • Atypical mycobacterial infection, disseminated(Pd);
  • Atypical mycobacterial infection, disseminated familial(Pd);
  • Atypical mycobacterial infection, familial disseminated(Pd);
  • BCG infection, generalized familial(Pd);
  • Bcg infection, generalized familial semibenign(Pd);
  • BCG infection, tuberculoid, antibiotic-responsive(Pd);
  • Helicobacter pylori infection, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00127 Entrez Gene ID: 3459 OMIM ID: 107470 Swissprot Accession: P15260;