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Description for Protein IFNG

interferon, gamma
5 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04687
    KEGG - Pathway(s):
    hsa03050; hsa04060; hsa04140; hsa04350; hsa04612; hsa04630; hsa04650; hsa04660; hsa04940; hsa05140; hsa05142; hsa05144; hsa05322; hsa05330; hsa05332
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Immune interferon; IFI; IFG; IFN gamma
    Approved Symbol:
    IFNG
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Glucosamine(db)

    Associated Genetic Diseases:

  • Acquired immunodeficiency syndrome, rapid progression to(Pd);
  • TSC2 angiomyolipomas, renal, modifier of(Pd);
  • Tuberculosis, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00957 Entrez Gene ID: 3458 OMIM ID: 147570 Swissprot Accession: P01579;