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Description for Protein IFNAR2

interferon (alpha, beta and omega) receptor 2
13 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05131
    KEGG - Pathway(s):
    hsa04060; hsa04620; hsa04630; hsa04650
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Interferon (alpha, beta and omega) receptor 2; IFN-R; Interferon alpha/beta receptor 2; IFNABR; IFNARB; IFN-alpha-REC; Type I interferon receptor; Interferon-alpha/beta receptor beta chain; Interferon alpha/beta receptor 2 isoform b precursor; Interferon alpha/beta receptor 2 isoform a precursor
    Approved Symbol:
    IFNAR2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Interferon Alfa-2a, Recombinant(db);
  • Interferon Alfa-2b, Recombinant(db);
  • Interferon alfa-n1(db);
  • Interferon alfa-n3(db);
  • Interferon alfacon-1(db);
  • Interferon beta-1a(db);
  • Interferon beta-1b(db);
  • Peginterferon alfa-2a(db);
  • Peginterferon alfa-2b(db)

    Associated Genetic Diseases:

  • Hepatitis b virus, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 1
  • Isoform 2 : 2
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 03850 Entrez Gene ID: 3455 OMIM ID: 602376 Swissprot Accession: Q9BUA0; P48551; Q15467;