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Description for Protein IFNAR1

interferon (alpha, beta and omega) receptor 1
23 total interacting proteins; 12 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • FN3: Fibronectin type 3 domain
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05130
    KEGG - Pathway(s):
    hsa04060; hsa04620; hsa04630; hsa04650
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    IFN receptor 1; Antiviral protein, alpha; AVP; IFNBR; IFNAR; Antiviral protein, beta type; Interferon (alpha, beta and omega) receptor 1; IFRC interferon, beta receptor; Interferon alpha/beta receptor alpha chain; IFN alpha REC
    Approved Symbol:
    IFNAR1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Interferon Alfa-2a, Recombinant(db);
  • Interferon Alfa-2b, Recombinant(db);
  • Interferon alfa-n1(db);
  • Interferon alfa-n3(db);
  • Interferon alfacon-1(db);
  • Interferon beta-1a(db);
  • Interferon beta-1b(db);
  • Peginterferon alfa-2a(db);
  • Peginterferon alfa-2b(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 00126 Entrez Gene ID: 3454 OMIM ID: 107450 Swissprot Accession: P17181;