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Description for Protein APOC3

apolipoprotein C-III
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(platelet: 3)
Summary:
Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08759
    KEGG - Pathway(s):
    hsa03320
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Apo CIII
    Approved Symbol:
    APOC3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Apolipoprotein c-III deficiency(Pd);
  • Apolipoprotein c-III, nonglycosylated(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00132 Entrez Gene ID: 345 OMIM ID: 107720 Swissprot Accession: P02656; A3KPE2;