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Description for Protein APOC2

apolipoprotein C-II
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    ApoC-II
    Approved Symbol:
    APOC2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Apolipoprotein C-II (African)(Pd);
  • Apolipoprotein C-II (Auckland)(Pd);
  • Apolipoprotein C-II (Bari)(Pd);
  • Apolipoprotein C-II (Hamburg)(Pd);
  • Apolipoprotein C-II (Nijmegen)(Pd);
  • Apolipoprotein C-II (Padova)(Pd);
  • Apolipoprotein C-II (Paris)(Pd);
  • Apolipoprotein C-II (San Francisco)(Pd);
  • Apolipoprotein C-II (St. Michael)(Pd);
  • Apolipoprotein C-II (Toronto)(Pd);
  • Apolipoprotein C-II (Wakayama)(Pd);
  • Apolipoprotein C-II variant(Pd);
  • Apolipoprotein C-II variants, molecular defect unknown(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07457 Entrez Gene ID: 344 OMIM ID: 608083 Swissprot Accession: P02655;