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Description for Protein IDS

iduronate 2-sulfatase
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked Mucopolysaccharidosis Type II, also known as Hunter Syndrome. Iduronate-2-sulfatase has a strong sequence similarity with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.6.13
    KEGG - Orthology:
    K01136
    KEGG - Pathway(s):
    hsa00531; hsa01100; hsa04142
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MPS II; MPS2; SIDS; EC 3.1.6.13; Alpha-L-iduronate sulfate sulfatase; Idursulfase; Iduronate-2-sulfatase isoform b precursor; Iduronate-2-sulfatase isoform a precursor
    Approved Symbol:
    IDS
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Mucopolysaccharidosis type II(Pd);
  • Mucopolysaccharidosis type II, intermediate form(Pd);
  • Mucopolysaccharidosis type II, mild form(Pd);
  • Mucopolysaccharidosis type II, severe form(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02402 Entrez Gene ID: 3423 OMIM ID: 309900 Swissprot Accession: B4DGD7; P22304; Q9BRM3;