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Description for Protein IDH3B

isocitrate dehydrogenase 3 (NAD+) beta
5 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.1.1.41
    KEGG - Orthology:
    K00030
    KEGG - Pathway(s):
    hsa00020; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    H-IDHB; MGC903; FLJ11043; Isocitrate dehydrogenase 3, beta subunit isoform a precursor; Isocitrate dehydrogenase 3, beta subunit isoform b precursor; Isocitrate dehydrogenase 3, beta subunit isoform c; EC 1.1.1.41; Isocitrate dehydrogenase 3 beta subunit; Isocitrate dehydrogenase, NAD(+) specific, mitochondrial, beta subunit; Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial; NAD+ specific ICDH; Isocitric dehydrogenase; NAD+ specific isocitrate dehydrogenase b subunit
    Approved Symbol:
    IDH3B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • NADH(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05163 Entrez Gene ID: 3420 OMIM ID: 604526 Swissprot Accession: O43837; Q9NUZ0;