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Description for Protein IDH3A

isocitrate dehydrogenase 3 (NAD+) alpha
5 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(platelet: 3)
Summary:
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.1.1.41
KEGG - Orthology:
K00030
KEGG - Pathway(s):
hsa00020; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Isocitrate dehydrogenase, NAD(+) specific, mitochondrial, alpha; Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; NAD+ specific ICDH; NAD(H) specific isocitrate dehydrogenase alpha subunit precursor; Isocitrate dehydrogenase (NAD+) alpha chain precursor; H-IDH alpha; Isocitric dehydrogenase
Approved Symbol:
IDH3A
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • NADH(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03094 Entrez Gene ID: 3419 OMIM ID: 601149 Swissprot Accession: P50213;