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Description for Protein IDH2

isocitrate dehydrogenase 2 (NADP+), mitochondrial
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 10/1)
(membrane: 2; microparticles: 1; platelet: 6; secretome: 1; undefined: 1)
Summary:
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.1.1.42
KEGG - Orthology:
K00031
KEGG - Pathway(s):
hsa00020; hsa00480; hsa01100; hsa04146
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Isocitrate dehydrogenase [NADP], mitochondrial; Isocitrate dehydrogenase, NADP[+] specific, mitochondrial; ICD-M; NADP+ specific ICDH; IDP; Oxalosuccinate decarboxylase; IDH; IDHM; mNADP IDH; EC 1.1.1.42
Approved Symbol:
IDH2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 3
Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Isocitric Acid(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00973 Entrez Gene ID: 3418 OMIM ID: 147650 Swissprot Accession: P48735;