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Description for Protein IDH1

isocitrate dehydrogenase 1 (NADP+), soluble
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 6/1)
(microparticles: 1; platelet: 6; secretome: 1)
Summary:
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.1.1.42
KEGG - Orthology:
K00031
KEGG - Pathway(s):
hsa00020; hsa00480; hsa01100; hsa04146
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Isocitrate dehydrogenase, NADP[+]-specific, soluble; Isocitrate dehydrogenase [NADP] cytoplasmic; NADP dependent isocitrate dehydrogenase, peroxisomal; PICD; IDP; Oxalosuccinate decarboxylase; IDH; EC 1.1.1.42
Approved Symbol:
IDH1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 5
Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2'-Monophosphoadenosine 5'-Diphosphoribose(db);
  • Isocitric Acid(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00984 Entrez Gene ID: 3417 OMIM ID: 147700 Swissprot Accession: O75874; Q6FHQ6;