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Description for Protein ACADM

acyl-CoA dehydrogenase, C-4 to C-12 straight chain
4 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 3; secretome: 2)
Summary:
This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.3.99.3
KEGG - Orthology:
K00249
KEGG - Pathway(s):
hsa00071; hsa00280; hsa00410; hsa00640; hsa01100; hsa03320
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
MCAD; MCADH
Approved Symbol:
ACADM
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 3-Thiaoctanoyl-Coenzyme A(db);
  • Flavin-Adenine Dinucleotide(db);
  • Octanoyl-Coenzyme A(db)

    Associated Genetic Diseases:

  • MCAD deficiency(Pd);
  • MCAD deficiency, modifier of(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08447 Entrez Gene ID: 34 OMIM ID: 607008 Swissprot Accession: P11310;