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Description for Protein ICAM1

intercellular adhesion molecule 1
13 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(: 1)
Summary:
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • Ig_LIKE: Immunoglobulin like
  • IG: Immunoglobulin
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06490
    KEGG - Pathway(s):
    hsa04514; hsa04650; hsa04670; hsa05144; hsa05416
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CD54; Major group rhinovirus receptor; Surface antigen of activated B cells, BB2; CD54 antigen
    Approved Symbol:
    ICAM1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Natalizumab(db)

    Associated Genetic Diseases:

  • Malaria, cerebral, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00996 Entrez Gene ID: 3383 OMIM ID: 147840 Swissprot Accession: P05362;