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Description for Protein HTR7

5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04163
    KEGG - Pathway(s):
    hsa04020; hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    5-hydroxytryptamine receptor 7; 5-HT-7; 5-HT-X serotonin receptor; 5HT7; 5-HT-X; Serotonin receptor 7; 5HT7d; 5-hydroxytryptamine receptor 7 isoform a; 5-hydroxytryptamine receptor 7 isoform b; 5-hydroxytryptamine receptor 7 isoform d
    Approved Symbol:
    HTR7
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Amisulpride(db);
  • Aripiprazole(db);
  • Bromocriptine(db);
  • Cabergoline(db);
  • Clozapine(db);
  • Eletriptan(db);
  • Epinastine(db);
  • Methysergide(db);
  • Olanzapine(db);
  • Quetiapine(db);
  • Ziprasidone(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 7
  • Isoform 2 : 7
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 01639 Entrez Gene ID: 3363 OMIM ID: 182137 Swissprot Accession: P34969; Q5VX03;