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Description for Protein HTR3A

5-hydroxytryptamine (serotonin) receptor 3A
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04819
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    5-hydroxytryptamine receptor 3; HTR3; 5HT3R; Serotonin-gated ion channel receptor; 5-HT3A; Serotonin 5-HT-3 receptor; 5-hydroxytryptamine (serotonin) receptor 3A isoform a precursor; 5-hydroxytryptamine (serotonin) receptor 3A isoform b precursor; 5-HT-3; Serotonin receptor; 5HT3 serotonin receptor
    Approved Symbol:
    HTR3A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alosetron(db);
  • Aripiprazole(db);
  • Chloroprocaine(db);
  • Cisapride(db);
  • Clozapine(db);
  • Dolasetron(db);
  • Granisetron(db);
  • Memantine(db);
  • Mirtazapine(db);
  • Olanzapine(db);
  • Ondansetron(db);
  • Palonosetron(db);
  • Procaine(db);
  • Quetiapine(db);
  • Rocuronium(db);
  • Tubocurarine(db);
  • Ziprasidone(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 4
  • Isoform 1 : 4
    • Additional Identifiers:

    HPRD: 08917 Entrez Gene ID: 3359 OMIM ID: 182139 Swissprot Accession: P46098; Q7KZM7; B4E398;