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Description for Protein HTR2C

5-hydroxytryptamine (serotonin) receptor 2C
8 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04159
    KEGG - Pathway(s):
    hsa04020; hsa04080; hsa04540
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Serotonin 5-HT-2C receptor; 5-hydroxytryptamine (serotonin) receptor 2C; Serotonin 5-HT-1C receptor; HTR1C; 5-hydroxytryptamine 2C receptor; 5-HT-2C
    Approved Symbol:
    HTR2C
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 3,4-Methylenedioxymethamphetamine(db);
  • Apomorphine(db);
  • Aripiprazole(db);
  • Bromocriptine(db);
  • Cabergoline(db);
  • Chlorprothixene(db);
  • Clomipramine(db);
  • Clozapine(db);
  • Cyproheptadine(db);
  • Dexfenfluramine(db);
  • Doxepin(db);
  • Fenfluramine(db);
  • Lisuride(db);
  • Loxapine(db);
  • Methotrimeprazine(db);
  • Methysergide(db);
  • Mianserin(db);
  • Minaprine(db);
  • Mirtazapine(db);
  • Nefazodone(db);
  • Olanzapine(db);
  • Paliperidone(db);
  • Pergolide(db);
  • Pramipexole(db);
  • Promazine(db);
  • Propiomazine(db);
  • Quetiapine(db);
  • Risperidone(db);
  • Ropinirole(db);
  • Sertindole(db);
  • Tegaserod(db);
  • Tramadol(db);
  • Trazodone(db);
  • Yohimbine(db);
  • Ziprasidone(db)

    Associated Genetic Diseases:

  • Serotonin 5-HT-2C receptor polymorphism(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 8
    • Additional Identifiers:

    HPRD: 02429 Entrez Gene ID: 3358 OMIM ID: 312861 Swissprot Accession: P28335;