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Description for Protein HTR2B

5-hydroxytryptamine (serotonin) receptor 2B
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Multiple receptor subtypes of serotonin neurotransmitters with multiple physiologic functions have been recognized. The 5-HT-2 receptors mediate many of the central and peripheral physiologic functions of serotonin. Cardiovascular effects include contraction of blood vessels and shape changes in platelets; central nervous system effects include neuronal sensitization to tactile stimuli and mediation of hallucinogenic effects of phenylisopropylamine hallucinogens.[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04158
    KEGG - Pathway(s):
    hsa04020; hsa04080; hsa04540
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Serotonin 5-HT-2B receptor
    Approved Symbol:
    HTR2B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 3,4-Methylenedioxymethamphetamine(db);
  • Apomorphine(db);
  • Bromocriptine(db);
  • Cabergoline(db);
  • Chlorprothixene(db);
  • Clomipramine(db);
  • Dihydroergotamine(db);
  • Doxepin(db);
  • Eletriptan(db);
  • Fenfluramine(db);
  • Lisuride(db);
  • Methysergide(db);
  • Minaprine(db);
  • Pergolide(db);
  • Pramipexole(db);
  • Ropinirole(db);
  • Tegaserod(db);
  • Triflupromazine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 03077 Entrez Gene ID: 3357 OMIM ID: 601122 Swissprot Accession: P41595;