Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein HTR2A

5-hydroxytryptamine (serotonin) receptor 2A
16 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04157
    KEGG - Pathway(s):
    hsa04020; hsa04080; hsa04540
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    5-hydroxytryptamine receptor 2A; Serotonin 5-HT-2 receptor; HTR2
    Approved Symbol:
    HTR2A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 3,4-Methylenedioxymethamphetamine(db);
  • Acepromazine(db);
  • Amisulpride(db);
  • Amitriptyline(db);
  • Aniracetam(db);
  • Apomorphine(db);
  • Aripiprazole(db);
  • Bromocriptine(db);
  • Cabergoline(db);
  • Chlorpromazine(db);
  • Chlorprothixene(db);
  • Cinitapride(db);
  • Cisapride(db);
  • Clomipramine(db);
  • Clozapine(db);
  • Cyclobenzaprine(db);
  • Cyproheptadine(db);
  • Desipramine(db);
  • Dihydroergotoxine(db);
  • Dimethyltryptamine(db);
  • Donepezil(db);
  • Doxepin(db);
  • Epinastine(db);
  • Ergotamine(db);
  • Fluoxetine(db);
  • Flupenthixol(db);
  • Fluspirilene(db);
  • Haloperidol(db);
  • Imipramine(db);
  • Lisuride(db);
  • Loxapine(db);
  • Mesoridazine(db);
  • Methotrimeprazine(db);
  • Methysergide(db);
  • Mianserin(db);
  • Minaprine(db);
  • Mirtazapine(db);
  • MMDA(db);
  • Molindone(db);
  • Nefazodone(db);
  • Nortriptyline(db);
  • Olanzapine(db);
  • Paliperidone(db);
  • Paroxetine(db);
  • Pergolide(db);
  • Pipotiazine(db);
  • Pramipexole(db);
  • Promazine(db);
  • Promethazine(db);
  • Propiomazine(db);
  • Quetiapine(db);
  • Remoxipride(db);
  • Risperidone(db);
  • Ropinirole(db);
  • Sertindole(db);
  • Tegaserod(db);
  • Thioproperazine(db);
  • Thioridazine(db);
  • Thiothixene(db);
  • Trazodone(db);
  • Trimipramine(db);
  • Yohimbine(db);
  • Ziprasidone(db);
  • Zuclopenthixol(db)

    Associated Genetic Diseases:

  • Major depressive disorder, response to citalopram therapy in(Pd);
  • Obsessive-compulsive disorder, susceptibility to(Pd);
  • Schizophrenia, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 01638 Entrez Gene ID: 3356 OMIM ID: 182135 Swissprot Accession: P28223; B4DZ79;