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Description for Protein HTR1B

5-hydroxytryptamine (serotonin) receptor 1B
5 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992 [PubMed 1359584]). The serotonergic receptors belong to the multigene family of receptors coupled to guanine nucleotide-binding proteins.[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04154
    KEGG - Pathway(s):
    hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    5 hydroxytryptamine receptor 1B; HTR1DB; S12
    Approved Symbol:
    HTR1B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Almotriptan(db);
  • Apomorphine(db);
  • Aripiprazole(db);
  • Bopindolol(db);
  • Bromocriptine(db);
  • Cabergoline(db);
  • Clozapine(db);
  • Dihydroergotamine(db);
  • Eletriptan(db);
  • Ergotamine(db);
  • Frovatriptan(db);
  • Lisuride(db);
  • Naratriptan(db);
  • Olanzapine(db);
  • Ondansetron(db);
  • Pergolide(db);
  • Pindolol(db);
  • Pramipexole(db);
  • Propranolol(db);
  • Quetiapine(db);
  • Rizatriptan(db);
  • Ropinirole(db);
  • Sumatriptan(db);
  • Yohimbine(db);
  • Ziprasidone(db);
  • Zolmitriptan(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 01634 Entrez Gene ID: 3351 OMIM ID: 182131 Swissprot Accession: P28222;