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Description for Protein APOA1

apolipoprotein A-I
25 total interacting proteins; 16 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 7/1)
(membrane: 1; platelet: 4; secretome: 2; undefined: 1)
Summary:
This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08757
    KEGG - Pathway(s):
    hsa03320
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Apolipoprotein of high density lipoprotein; Apo AI
    Approved Symbol:
    APOA1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Amyloid polyneuropathy-nephropathy, Iowa type(Pd);
  • Amyloidosis, cardiac and cutaneous(Pd);
  • Amyloidosis, hepatic and systemic(Pd);
  • Amyloidosis, systemic nonneuropathic(Pd);
  • Analphalipoproteinemia(Pd);
  • Apolipoprotein A-I(Pd);
  • Apolipoprotein A-I (Baltimore)(Pd);
  • Apolipoprotein A-I (Giessen)(Pd);
  • Apolipoprotein A-I (Marburg)(Pd);
  • Apolipoprotein A-I (Milano)(Pd);
  • Apolipoprotein A-I (Oita)(Pd);
  • Apolipoprotein A-I deficiency(Pd);
  • Apolipoprotein A-I, absence of, due to deletion of apoa1/apoc3/APOA4 gene complex(Pd);
  • Corneal clouding due to Apolipoprotein A-I deficiency(Pd);
  • Hdl deficiency, Detroit type(Pd);
  • Hypoalphalipoproteinemia, primary(Pd);
  • Xanthelasmas, periorbital(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02517 Entrez Gene ID: 335 OMIM ID: 107680 Swissprot Accession: P02647;