Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein HSPD1

heat shock 60kDa protein 1 (chaperonin)
30 total interacting proteins; 20 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 8/2)
(membrane: 1; microparticles: 2; platelet: 6; secretome: 2; undefined: 1)
Summary:
This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04077
    KEGG - Pathway(s):
    hsa03018; hsa04940
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    HSP65; SPG13; Heat shock protein 65; Short heat shock protein 60 Hsp60s1; Chaperonin; GroEL homolog; Chaperonin 60 homolog; cpn60 homolog; 60 kDa heat shock protein, mitochondrial; Hsp60; 60 kDa chaperonin; CPN60; Heat shock protein 60; Mitochondrial matrix protein P1; P60 lymphocyte protein; HuCHA60
    Approved Symbol:
    HSPD1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 13
    Human (de-) phosphorylation sites: 13; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Spastic paraplegia 13(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00318 Entrez Gene ID: 3329 OMIM ID: 118190 Swissprot Accession: P10809;