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Description for Protein BIRC5

baculoviral IAP repeat-containing 5
25 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this gene's expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • BIR: Baculoviral inhibition of apoptosis protein repeat
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08731
    KEGG - Pathway(s):
    hsa05200; hsa05210
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Apoptosis inhibitor 4; Baculoviral IAP repeat containing protein 5; Apoptosis inhibitor survivin; API4; IAP4; EPR-1; Baculoviral IAP repeat containing protein 5 isoform 2; Baculoviral IAP repeat-containing protein 5 isoform 3; Baculoviral IAP repeat-containing protein 5 isoform 1
    Approved Symbol:
    BIRC5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04520 Entrez Gene ID: 332 OMIM ID: 603352 Swissprot Accession: O15392;