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Description for Protein HSPB1

heat shock 27kDa protein 1
33 total interacting proteins; 16 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 12/1)
(membrane: 2; microparticles: 1; phosphoproteome: 1; platelet: 7; secretome: 1; undefined: 1)
Summary:
The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K04455
KEGG - Pathway(s):
hsa04010; hsa04370
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
HSP27; Heat shock 27kDa protein 1; Heat shock protein beta 1; Stress responsive protein 27; SRP27; Estrogen regulated 24 kDa protein; HSP28; 28 kDa heat shock protein
Approved Symbol:
HSPB1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 16
Human (de-) phosphorylation sites: 16; Platelet phosphorylation sites: 2
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Charcot-Marie-tooth disease, axonal, type 2F(Pd);
  • Neuronopathy, distal hereditary motor, type IIb(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09076 Entrez Gene ID: 3315 OMIM ID: 602195 Swissprot Accession: P04792;