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Description for Protein HSPA8

heat shock 70kDa protein 8
87 total interacting proteins; 40 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 12/1)
(ATP binding: 1; membrane: 2; microparticles: 1; platelet: 9; secretome: 1)
Summary:
The product encoded by this gene belongs to the heat shock protein 70 family which contains both heat-inducible and constitutively expressed members. The latter are called heat-shock cognate proteins. This gene encodes a heat-shock cognate protein. This protein binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Two alternatively spliced variants have been characterized to date. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NES: Nuclear Export Signal
  • NLS: Nuclear localization signal
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03283
    KEGG - Pathway(s):
    hsa03040; hsa04010; hsa04144; hsa04612
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    LPS associated protein 1; Heat shock 70 kDa protein 10; Heat shock cognate protein 54; Constitutive heat shock protein 70; Heat shock cognate protein, 71 kDa; Lipopolysaccharide associated protein 1; N-myristoyltransferase inhibitor protein 71; Uncharacterized bone marrow protein BM034; LAP1; HSC70; HSC71; HSP71; HSP73; HSPA10; MGC29929; NIP71; Heat shock 70kDa protein 8 isoform 2; Heat shock 70kDa protein 8 isoform 1
    Approved Symbol:
    HSPA8
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 30
    Human (de-) phosphorylation sites: 30; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol(db);
  • Adenosine-5'-Diphosphate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07205 Entrez Gene ID: 3312 OMIM ID: 600816 Swissprot Accession: P11142; B3KTV0;