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Description for Protein XIAP

X-linked inhibitor of apoptosis
49 total interacting proteins; 24 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of a family of proteins which inhibit apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. This protein inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. It also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • BIR: Baculoviral inhibition of apoptosis protein repeat
  • RING: Ring finger
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04725
    KEGG - Pathway(s):
    hsa04120; hsa04210; hsa04510; hsa04621; hsa05200; hsa05222
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    XIAP; Baculoviral IAP repeat containing protein 4; API3; Mammalian IAP homolog A; MIHA; Inhibitor of apoptosis protein 3; X-linked inhibitor of apoptosis protein; X-linked IAP; HILP; IAP Like protein; ILP
    Approved Symbol:
    XIAP
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 7
    Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide(db);
  • N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE(db)

    Associated Genetic Diseases:

  • Lymphoproliferative syndrome, X-linked, 2(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02094 Entrez Gene ID: 331 OMIM ID: 300079 Swissprot Accession: P98170;