Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein HSPA5

heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
53 total interacting proteins; 23 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 13/1)
(alpha granules: 1; ATP binding: 1; membrane: 2; microparticles: 1; platelet: 9; secretome: 1)
Summary:
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09490
    KEGG - Pathway(s):
    hsa03060; hsa04612; hsa05020
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Glucose related protein 78KD; GRP78; Immunoglobulin heavy chain binding-protein; Heat shock 70kD protein 5; Endoplasmic reticulum lumenal Ca(2+) binding protein grp78
    Approved Symbol:
    HSPA5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 1
    Human phosphorylation targets: 1; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Antihemophilic Factor(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00682 Entrez Gene ID: 3309 OMIM ID: 138120 Swissprot Accession: P11021;