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Description for Protein HSPA1A

heat shock 70kDa protein 1A
80 total interacting proteins; 38 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 10/0)
(ATP binding: 2; membrane: 4; microparticles: 2; platelet: 9)
Summary:
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03283
    KEGG - Pathway(s):
    hsa03040; hsa04010; hsa04144; hsa04612; hsa05020
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Heat shock 70KD protein 1; HSPA1; HSP70 1; HSP72
    Approved Symbol:
    HSPA1A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine-5'-Diphosphate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00774 Entrez Gene ID: 3303 OMIM ID: 140550 Swissprot Accession: P08107; B3KTT5; A8K5I0;