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Description for Protein BIRC3

baculoviral IAP repeat-containing 3
40 total interacting proteins; 23 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • BIR: Baculoviral inhibition of apoptosis protein repeat
  • CC: Coiled Coil
  • CARD: Caspase recruitment domain
  • RING: Ring finger
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04725
    KEGG - Pathway(s):
    hsa04120; hsa04210; hsa04510; hsa04621; hsa05200; hsa05222
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Apoptosis inhibitor 2; cIAP2; TNFR2-TRAF signaling complex protein 1; API2; HIAP1; CIAP2; MIHC; IAP homolog C; Inhibitor of apoptosis protein 1; Mammalian IAP homolog C; AIP1; HAIP1; MALT2; RNF49
    Approved Symbol:
    BIRC3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03426 Entrez Gene ID: 330 OMIM ID: 601721 Swissprot Accession: Q13489; Q13490;