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Description for Protein HSD17B4

hydroxysteroid (17-beta) dehydrogenase 4
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 9/0)
(alpha granules: 1; membrane: 2; microparticles: 1; platelet: 11)
Summary:
The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.1.1.35; 4.2.1.107
KEGG - Orthology:
K12405
KEGG - Pathway(s):
hsa00120; hsa01100; hsa04146
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Multifuntional protein 2; MEP-2; Peroxisomal multifuntional enzyme2; MFE2; 17 beta HSD 4; D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein; D-bifunctional protein, peroxisomal; DBP, peroxisomal; EDH17B4; 2-trans-enoyl-CoA hydratase
Approved Symbol:
HSD17B4
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 13
Human (de-) phosphorylation sites: 13; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 3r-Hydroxydecanoyl-Coa(db);
  • NADH(db);
  • Nicotinamide-Adenine-Dinucleotide(db)

    Associated Genetic Diseases:

  • D-bifunctional protein deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03514 Entrez Gene ID: 3295 OMIM ID: 601860 Swissprot Accession: P51659;