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Description for Protein HSD17B3

hydroxysteroid (17-beta) dehydrogenase 3
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.1.1.64
    KEGG - Orthology:
    K10207
    KEGG - Pathway(s):
    hsa00140; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    17-beta-HSD 3; Estradiol 17 beta dehydrogenase; EDH17B3; Testicular 17 beta hydroxysteroid dehydrogenase 3
    Approved Symbol:
    HSD17B3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • NADH(db)

    Associated Genetic Diseases:

  • 17-@beta hydroxysteroid dehydrogenase III deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 3
    • Additional Identifiers:

    HPRD: 05716 Entrez Gene ID: 3293 OMIM ID: 605573 Swissprot Accession: Q6FH62; P37058;