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Description for Protein HES1

hairy and enhancer of split 1, (Drosophila)
24 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ORANGE: Orange domain
  • HLH: helix loop helix domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06054
    KEGG - Pathway(s):
    hsa04330; hsa04950
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    HRY; Hairy homolog; HHL; FLJ20408; Hairy-like; Transcription factor HES-1
    Approved Symbol:
    HES1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00770 Entrez Gene ID: 3280 OMIM ID: 139605 Swissprot Accession: Q14469;