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Description for Protein HRH2

histamine receptor H2
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04150
    KEGG - Pathway(s):
    hsa04020; hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    H2R; Gastric receptor I
    Approved Symbol:
    HRH2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Betazole(db);
  • Cimetidine(db);
  • Doxepin(db);
  • Epinastine(db);
  • Famotidine(db);
  • Histamine Phosphate(db);
  • Methantheline(db);
  • Metiamide(db);
  • Nizatidine(db);
  • Ranitidine(db);
  • Roxatidine acetate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 7
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 00816 Entrez Gene ID: 3274 OMIM ID: 142703 Swissprot Accession: P25021; Q7Z5R9;