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Description for Protein HRAS

v-Ha-ras Harvey rat sarcoma viral oncogene homolog
78 total interacting proteins; 37 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/1)
(membrane: 1; platelet: 8; undefined: 1)
Summary:
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RAS: Ras subfamily of RAS small GTPases
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K02833
    KEGG - Pathway(s):
    hsa04010; hsa04012; hsa04062; hsa04144; hsa04360; hsa04370; hsa04510; hsa04530; hsa04540; hsa04650; hsa04660; hsa04662; hsa04664; hsa04720; hsa04722; hsa04730; hsa04810; hsa04910; hsa04912; hsa04916; hsa05200; hsa05211; hsa05213; hsa05214; hsa05215; hsa05216; hsa05218; hsa05219; hsa05220; hsa05221; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    RASH1; HRASP; C-H-RAS; HRAS1; Transforming protein p21/H-RAS-1; K-ras; N-ras; c-bas/has; G1III6 N-ras; H-RasIDX; N-ras oncogene (AA 1-37); C-H-ras-1 protein N-terminal fragment (37 AA); C-has/bas p21 protein; C-ras-Ki-2 protein; P21 protein; V-Ha-ras Harvey rat sarcoma viral oncogene homolog isofrom 1; V-Ha-ras Harvey rat sarcoma viral oncogene homolog isofrom 2; Ha-Ras; H-Ras-1
    Approved Symbol:
    HRAS
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2-Propanol, Isopropanol(db);
  • Guanosine-5'-Diphosphate(db);
  • Guanosine-5'-Triphosphate(db);
  • Hexane-1,6-Diol(db);
  • N,N'-DIMETHYL-N-(ACETYL)-N'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINE(db);
  • Trifluoroethanol(db)

    Associated Genetic Diseases:

  • Bladder cancer, somatic(Pd);
  • Costello syndrome(Pd);
  • Thyroid carcinoma, follicular, somatic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01813 Entrez Gene ID: 3265 OMIM ID: 190020 Swissprot Accession: P01112; Q9BR65;