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Description for Protein ACACB

acetyl-CoA carboxylase beta
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    6.3.4.14; 6.4.1.2
    KEGG - Orthology:
    K11262
    KEGG - Pathway(s):
    hsa00061; hsa00620; hsa00640; hsa01100; hsa04910; hsa04920
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    ACCB; Acetyl-CoA carboxylase 2; ACC beta; Biotin carboxylase; ACC2
    Approved Symbol:
    ACACB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (2S)-2-(4-{[3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDIN-2-YL]OXY}PHENOXY)PROPANOIC ACID(db);
  • 2-[4-(2,4-Dichlorophenoxy)Phenoxy]Propanoic Acid(db);
  • Adenine(db);
  • Biotin(db);
  • Soraphen A(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 07044 Entrez Gene ID: 32 OMIM ID: 601557 Swissprot Accession: O00763;