Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein HNRNPD

heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
32 total interacting proteins; 21 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RRM: RNA recognition motif
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K13044
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    AU rich element RNA binding protein 1, 37KD; AUF1; ARE binding protein AUF1, type A; AUF1A; AU-rich element RNA-binding protein 1; hnRNPD0; P37; Eterogeneous nuclear ribonucleoprotein D (AU-rich element RNA-binding protein 1, 37kD); Heterogeneous nuclear ribonucleoprotein D isoform d; Heterogeneous nuclear ribonucleoprotein D isoform c; Heterogeneous nuclear ribonucleoprotein D isoform b; Heterogeneous nuclear ribonucleoprotein D isoform a; p45; p42; p40; p37
    Approved Symbol:
    HNRNPD
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 12
    Human (de-) phosphorylation sites: 12; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03206 Entrez Gene ID: 3184 OMIM ID: 601324 Swissprot Accession: Q14103;