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Description for Protein HNRNPC

heterogeneous nuclear ribonucleoprotein C (C1/C2)
27 total interacting proteins; 15 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(platelet: 2)
Summary:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RRM: RNA recognition motif
  • LZ: Leucine Zipper
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12884
    KEGG - Pathway(s):
    hsa03040
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    HNRNP; SNRPC; hnRNPC; MGC104306; MGC105117; Heterogeneous nuclear ribonucleoproteins C1/C2; Heterogeneous nuclear ribonucleoprotein C isoform a; Heterogeneous nuclear ribonucleoprotein C isoform b
    Approved Symbol:
    HNRNPC
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 50
    Human (de-) phosphorylation sites: 50; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01243 Entrez Gene ID: 3183 OMIM ID: 164020 Swissprot Accession: P07910;