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Description for Protein HNRNPA2B1

heterogeneous nuclear ribonucleoprotein A2/B1
14 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RRM: RNA recognition motif
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K13158
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    HNRPA2; Heterogeneous nuclear ribonucleoprotein B1; HNRPB1; Nuclear ribonucleoprotein particle A2 protein; hnRNP A2; hnRNP B1; Heterogeneous nuclear ribonucleoprotein A2/B1; Heterogeneous nuclear ribonucleoprotein A2/B1 isoform A2; RNPA2; SNRPB1; HNRNPA2; HNRNPB1; Heterogeneous nuclear ribonucleoprotein A2/B1 isoform B1
    Approved Symbol:
    HNRNPA2B1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 42
    Human (de-) phosphorylation sites: 42; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02526 Entrez Gene ID: 3181 OMIM ID: 600124 Swissprot Accession: P22626;