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Description for Protein NUDT2

nudix (nucleoside diphosphate linked moiety X)-type motif 2
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and three transcript variants, all encoding the same protein, have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.6.1.17
KEGG - Orthology:
K01518
KEGG - Pathway(s):
hsa00230; hsa00240
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Nudix motif 2; AP4A hydrolase 1; APAH1; Bis 5` nucleosyl tetraphosphatase; Diadenosine 5` 5``` P1 P4 tetraphosphate asymmetrical hydrolase; Ap4Aase; Diadenosine 5` 5``` P1 P4 tetraphosphate pyrophosphohydrolase; Ap4A hydrolase; Nucleoside diphosphate linked moiety X motif 2; MGC10404; bis 5-nucleosyltetraphosphatase; EC 3.6.1.17
Approved Symbol:
NUDT2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04168 Entrez Gene ID: 318 OMIM ID: 602852 Swissprot Accession: P50583;