Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein HNF4A

hepatocyte nuclear factor 4, alpha
57 total interacting proteins; 17 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • HOLI: Ligand binding domain of hormone receptors
  • ZnF_C4: c4 zinc finger in nuclear hormone receptors
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07292
    KEGG - Pathway(s):
    hsa04950
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    HNF4 alpha; Hepatocyte nuclear factor 4; HNF4; Transcription factor 14, hepatic nuclear factor; TCF14; TCF; MODY; MODY1; NR2A1; HNF4a7; HNF4a8; HNF4a9; NR2A21; FLJ39654; Hepatocyte nuclear factor 4 alpha isoform b; Hepatocyte nuclear factor 4 alpha isoform a; Hepatocyte nuclear factor 4 alpha isoform c; Hepatocyte nuclear factor 4 alpha isoform d; Hepatocyte nuclear factor 4 alpha isoform f; Hepatocyte nuclear factor 4 alpha isoform e
    Approved Symbol:
    HNF4A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 20
    Human (de-) phosphorylation sites: 20; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Lauric Acid(db);
  • MYRISTIC ACID(db)

    Associated Genetic Diseases:

  • Maturity-onset diabetes of the young, type I(Pd);
  • Noninsulin-dependent diabetes mellitus(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02612 Entrez Gene ID: 3172 OMIM ID: 600281 Swissprot Accession: P41235;