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Description for Protein APAF1

apoptotic peptidase activating factor 1
18 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 3)
Summary:
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • WD40: WD40 repeats
  • CARD: Caspase recruitment domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K02084
    KEGG - Pathway(s):
    hsa04115; hsa04210; hsa05010; hsa05012; hsa05014; hsa05016; hsa05222
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Apoptotic protease activating factor1; CED4; KIAA0413; Apoptotic protease activating factor isoform a; Apoptotic protease activating factor isoform d; Apoptotic protease activating factor isoform b; Apoptotic protease activating factor isoform e; Apoptotic protease activating factor isoform c
    Approved Symbol:
    APAF1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine triphosphate(db);
  • Adenosine-5'-Diphosphate(db);
  • Beta-Mercaptoethanol(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03755 Entrez Gene ID: 317 OMIM ID: 602233 Swissprot Accession: O14727;