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Description for Protein HMOX1

heme oxygenase (decycling) 1
8 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.14.99.3
    KEGG - Orthology:
    K00510
    KEGG - Pathway(s):
    hsa00860
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    HO-1; HO; EC 1.14.99.3
    Approved Symbol:
    HMOX1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone(db);
  • 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE(db);
  • 12-Phenylheme(db);
  • 2-Phenylheme(db);
  • Biliverdine Ix Alpha(db);
  • Formic Acid(db);
  • Heme(db);
  • NADH(db);
  • Verdoheme(db)

    Associated Genetic Diseases:

  • Heme oxygenase 1 deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00782 Entrez Gene ID: 3162 OMIM ID: 141250 Swissprot Accession: P09601; Q6FH11;